Analysis of mutations leading to para-aminosalicylic acid resistance in Mycobacterium tuberculosis
نویسندگان
چکیده
منابع مشابه
Mechanisms involved in the resistance of Mycobacterium tuberculosis to para-aminosalicylic acid.
That para-aminobenzoic acid antagonizes competitively the inhibitory effect of paraaminosalicylic acid on the growth of Mycobacterium tuberculosis is well known. In a previous communication (Hedgecock, 1956) it was reported that inhibition of M. tuberculosis (strain H37Rv) by para-aminosalicylic acid was reversed noncompetitively by methionine and biotin when the concentration of the inhibitor ...
متن کاملMolecular genetics of para-aminosalicylic acid resistance in clinical isolates and spontaneous mutants of Mycobacterium tuberculosis.
The emergence of Mycobacterium tuberculosis resistant to first-line antibiotics has renewed interest in second-line antitubercular agents. Here, we aimed to extend our understanding of the mechanisms underlying para-aminosalicylic acid (PAS) resistance by analysis of six genes of the folate metabolic pathway and biosynthesis of thymine nucleotides (thyA, dfrA, folC, folP1, folP2, and thyX) and ...
متن کاملMycobacterium tuberculosis folate metabolism and the mechanistic basis for para-aminosalicylic acid susceptibility and resistance.
para-Aminosalicylic acid (PAS) entered clinical use in 1946 as the second exclusive drug for the treatment of tuberculosis (TB). While PAS was initially a first-line TB drug, the introduction of more potent antitubercular agents relegated PAS to the second-line tier of agents used for the treatment of drug-resistant Mycobacterium tuberculosis infections. Despite the long history of PAS usage, a...
متن کاملThe in Vitro Effect of Para-aminosalicylic Acid (pas) in Preventing Acquired Resistance to Streptomycin by Mycobacterium Tuberculosis.
Streptomycin was reported as being bacteriostatic and moderately bactericidal for Mycobacterium tuerculo8s by Schatz and Waksman (1944). These results were confirmed and extended by Youmans (1945), who reported that the drug was bacteriostatic at concentrations of 0.095 to 0.28 units per ml and bactericidal at concentrations in excess of 50 units per ml. Additional confirmatory observations hav...
متن کاملPara-aminosalicylic acid acts as an alternative substrate of folate metabolism in Mycobacterium tuberculosis.
Folate biosynthesis is an established anti-infective target, and the antifolate para-aminosalicylic acid (PAS) was one of the first anti-infectives introduced into clinical practice on the basis of target-based drug discovery. Fifty years later, PAS continues to be used to treat tuberculosis. PAS is assumed to inhibit dihydropteroate synthase (DHPS) in Mycobacterium tuberculosis by mimicking th...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2019
ISSN: 2045-2322
DOI: 10.1038/s41598-019-48940-5